This Could Help ALS Neurons Mellow Out
The antiepileptic drug ezogabine reduced pathologic excitability of cortical and spinal motor neuron cells that are early signs of clinical dysfunction in people with amyotrophic lateral sclerosis (ALS)
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FDA Names Synchron’s Stentrode Brain-Computer Interface a Breakthrough Device
The US Food and Drug Administration (FDA) has granted Breakthrough Device designation for Stentrode, an implantable medical device designed to translate brain activity or stimulate the nervous system from the inside of a blood vessel, without the need for open brain surgery, Synchron announces in a media release.
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HealthWell Foundation Launches New Fund to Assist ALS Patients
Independent nonprofit HealthWell Foundation announces the launch of a new fund to provide assistance to patients living with amyotrophic lateral sclerosis (ALS).
Keeping the Lines Open in ALS
Restoring the protein SV2 in a genetic form of ALS can correct abnormalities in transmission and even prevent cells from dying, providing a new target for future therapies, according to researchers.
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Pearly Whites and ALS… Oh, My
Mount Sinai scientists suggest they have identified biological markers in the teeth of patients who went on to develop amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease.
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Is This the New Mechanism Behind Upper Motor Degeneration?
Scientists from Northwestern Medicine and the University of Belgrade suggest they have pinpointed the electrophysiological mechanism behind upper motor neuron (UMN) disease, unlocking the door to potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
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Dutch Bros Coffee Customers ‘Drink One for Dane’ to Fight ALS
Dutch Bros Coffee and its customers joined together to raise $1.39 million for the Muscular Dystrophy Association (MDA) on the company’s 14th annual Drink One For Dane day held on May 8. More than 390 shops in seven states joined together with customers to support ALS research, patient care and advocacy.
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Harvard Scientists ID How the Gut and Brain Influences ALS
In mice with a common ALS genetic mutation, changing the gut microbiome using antibiotics or fecal transplants could prevent or improve disease symptoms, according to scientists from Harvard University.
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Could a Synaptic Safety Mechanism Provide Resilience to ALS?
A self-corrective mechanism at synapse doubles the lifespan of mice with ALS and suggests a new approach to therapy for human brain diseases, researchers from University of California – San Francisco note, in Neuron.
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Brain Hyperexcitability a Possible ALS Cause and Treatment Path
A team of researchers led by scientists at the University of Toronto (U of T) has delayed the onset of amyotrophic lateral sclerosis (ALS) in mice. They are cautiously optimistic that the result, combined with other clinical advances, points to a potential treatment for ALS in humans.
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Facebook Live Q&A: How to Protect the ALS Community During COVID-19
The Muscular Dystrophy Association (MDA) will host a special virtual conversation on Facebook Live about the precautions and best practices needed to protect the ALS community amid the COVID-19 pandemic, on Friday, May 1, from 3 pm to 3:30 PM ET.
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People with Disabilities, Take These Precautions to Protect Against COVID-19
People with conditions such as spinal cord injury, Lou Gehrig’s disease, and multiple sclerosis are at risk of developing severe respiratory problems related to COVID-19 because the muscles that help them breathe already may not function normally.
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Age and Sex Strongly Influence ALS Type and Symptoms, Study Finds
The onset and early progression of motor and cognitive symptoms, specific by disease type to each amyotrophic lateral sclerosis (ALS) patient, are determined by age and sex, and to some extend by mutations in ALS genes, a large data study has found, ALS News Today reports.
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This Gene Affects ALS Progression, Researchers Discover
Researchers from the Zuckerman Institute at Columbia University announce, in the journal Neuron, they have successfully found a gene that could work toward accelerating the progression of ALS or amyotrophic lateral sclerosis.
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Post-hoc Analysis of Phase 3 Endaravone Study Presented During Online MDA Conference
Mitsubishi Tanabe Pharma America Inc recently presented results from a post-hoc analysis assessing its Phase 3 edaravone study reviewing functional changes in both bulbar and limb onset patients with amyotrophic lateral sclerosis (ALS).
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New Disability Scale Better Assesses ALS Outcomes
NEW YORK (Reuters Health) – A new amyotrophic lateral sclerosis (ALS) disability scale (ROADS) that uses the mathematically rigorous Rasch methodology outperforms the revised ALS Functional Rating Scale (ALSFRS-R) in measuring ALS patient-reported outcomes, researchers report.
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Children and Teens as ALS Caregivers Need Training and Support, Study Opines
Children and teens with family members with amyotrophic lateral sclerosis, or ALS, help with bathing, dressing, eating and all types of caregiving activities, yet they may not have training or enough information about the disease, researchers suggest.
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Amino Acid May Be Useful in Treating ALS
L-serine, a naturally occurring amino acid, is gaining increased attention from scientists as a possible treatment for ALS following a new study published recently in the Journal of Neuropathology & Experimental Neurology that suggests L-serine successfully reduced ALS-like changes in an animal model of ALS.
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