Summary: 

Researchers at Binghamton University are developing biodegradable papertronics-based dressings that combine bacteria-fueled biobatteries and antibacterial agents to enhance wound healing and prevent infections.

Key Takeaways:

  1. The dressings incorporate spore-forming bacteria that produce antibacterial agents and activate only on the wound, ensuring long-term storage and effectiveness.
  2. Copper oxide and tin oxide nanoparticles in the dressings generate electrical currents that disrupt harmful biofilms and stimulate healing.
  3. Early tests on simulated and pig skin are promising, but further research is needed to understand the mechanisms and optimize the treatment for human use.

New research on wound care at Binghamton University, State University of New York combines ideas about biodegradable papertronics and bacteria-fueled biobatteries.

When wounds happen, we want them to heal quickly and without complications, but sometimes infections and other complications prevent it. Chronic wounds are a significant health concern affecting tens of millions of Americans.

Further Reading: Nano Drug Shows Promise for Diabetic Wound Healing

Binghamton University Professor Seokheun “Sean” Choi, PhD, has some ideas about how to improve the healing process, pulling together his recent research on biodegradable papertronics and bacteria-fueled biobatteries.

In a new paper published in the journal ACS Applied Materials & Interfaces, Choi and two PhD students from his Bioelectronics and Microsystems Lab—Maryam Rezaie and Zahra Rafiee—propose therapeutic dressings that inhibit dangerous biofilms by incorporating spore-forming bacteria that produce antibacterial agents as well as controlled electrical stimulation powered by biobatteries.

“We have very beneficiary skin bacteria that facilitate systematic immune defense. When you have a wound, this skin bacteria help with healing,” says Choi, a faculty member at the Thomas J. Watson College of Engineering and Applied Science’s Department of Electrical and Computer Engineering. “The problem is that this environment is perfect for pathogen invasion because it’s nutrient-rich, moist, and warm. When they start to form a biofilm, it’s really hard to eradicate those pathogens, and the wound-healing process can be extended, sometimes for a year or longer.”

The Binghamton team improves on previous research on live bacterial therapeutics in several ways. The bacteria are better integrated into the dressings and stay dormant until they activate on the wound itself, allowing for long-term storage. As long as there are nutrients, they will produce an almost unlimited number of antibacterial agents.

Improving antibacterial effectiveness even further, the team successfully added copper oxide and tin oxide nanoparticles to the spore-carrying bacteria to generate a tiny amount of power. When channeled into the wound area, the electric current seems to break down the cell integrity of the infecting microbes and stimulate healing.

The researchers tested their paper-based dressing utilizing biodegradable papertronics on simulated human skin and pig skin with promising results, but more investigation is required before the process is ready for human use.

“The beauty of using paper is that it is disposable, so you don’t need to worry about a second infection after you use it, but the future work is necessary,” Choi says. “We don’t clearly understand how this electrical stimulation heals the wound infections. One guess is that the membranes of a bacterial cells were damaged, but the type of electrical stimulation or how long in duration or how frequently to make it effective is something we need to study further.”

Featured image: New research on wound care at Binghamton University, State University of New York combines ideas about biodegradable papertronics and bacteria-fueled biobatteries. Credit: Seokheun “Sean” Choi