A fully implanted deep brain stimulation system features stimulating and sensing electrodes that are implanted in the brain and connect to small computer under the skin. Data from this computer can be read by an external device. (Photo courtesy of Ken Probst/Starr lab)
Research funded by the NIH BRAIN Initiative describes a fully implanted deep brain stimulation (DBS) system that tunes itself using feedback from the brain. It suggests that this system could help develop a better way to manage Parkinson’s symptoms.
“The novel approach taken in this small-scale feasibility study may be an important first step in developing a more refined or personalized way for doctors to reduce the problems patients with Parkinson’s disease face every day,” says Nick B. Langhals, PhD, program director at the National Institute of Neurological Disorders and Stroke (NINDS) and team lead for the Brain Research through Advancing Innovative Technologies (BRAIN) Initiative, in a media release.
Deep brain stimulation is a method of managing Parkinson’s disease symptoms by surgically implanting an electrode, a thin wire, into the brain. Traditional deep brain stimulation delivers constant stimulation to a part of the brain called the basal ganglia to help treat the symptoms of Parkinson’s. However, this approach can lead to unwanted side effects, requiring reprogramming by a trained clinician. The new method described in this study is adaptive, so that the stimulation delivered is responsive in real time to signals received from the patient’s brain.
The fully implanted device differs from traditional ones in that it can both monitor and modulate brain activity. In this work, sensing was done from an electrode implanted over the primary motor cortex, a part of the brain critical for normal movement. Signals from this electrode are then fed into a computer program embedded in the device, which determines whether to stimulate the brain, the release explains.
In the study, which was published in the Journal of Neural Engineering, two patients with Parkinson’s received a fully implanted, adapted deep brain stimulation device.
Researchers taught the program to recognize a pattern of brain activity associated with dyskinesia, or uncontrolled movements that are a side effect of deep brain stimulation in Parkinson’s disease, as a guide to tailor stimulation. Stimulation was reduced when it identified dyskinesia-related brain activity and increased when brain sensing indicated no dyskinesia to minimize deep brain stimulation-related side effects.
“This is the first time a fully implanted device has been used for closed-loop, adaptive deep brain stimulation in human Parkinson’s disease patients,” states Philip Starr, MD, PhD, professor of neurological surgery, University of California, San Francisco, and senior author of the study.
Results of initial, short-term studies aimed at demonstrating feasibility and effectiveness of using adaptive deep brain stimulation to overcome the impediment to movement of Parkinson’s suggested that this adaptive approach was equally effective at controlling symptoms as traditional deep brain stimulation. Doctors saw and patients noticed no differences in the improvement in movement under adaptive stimulation versus constant, open loop stimulation set manually by the researchers.
Because adaptive deep brain stimulation did not continuously stimulate the brain, the system saved about 40% of the device’s battery energy used during traditional stimulation. The short time periods over which movement was assessed did not permit comparison of the two deep brain stimulation paradigms relative to incidence of dyskinesia, but it is hoped that the variable stimulation will also translate into a reduction in adverse effects when tested over longer time periods, the release continues.
“Other adaptive deep brain stimulation designs record brain activity from an area adjacent to where the stimulation occurs, in the basal ganglia, which is susceptible to interference from stimulation current,” Starr continues. “Instead, our device receives feedback from the motor cortex, far from the stimulation source, providing a more reliable signal.”
Many patients with Parkinson’s disease who would benefit from deep brain stimulation are difficult to treat because too much stimulation can cause dyskinesia. Thus, finding the correct level of stimulation is like trying to hit a constantly moving target. An adaptive system like the one being tested here could offer an effective alternative and may also limit adverse effects of traditional deep brain stimulation, but considerable testing remains to be done, the release suggests.
“Here we have demonstrated the feasibility of adaptive deep brain stimulation,” Starr concludes. “We are now planning larger, longer-term trials to determine how effective this system is in managing the symptoms of patients with Parkinson’s disease.”
[Source: National Institutes of Health]
