The discovery of a new pathway leading to the regeneration of central nervous system (CNS) brain cells (neurons) in a type of roundworm (C. elegans) may help lead to treatments that help enhance nerve cell regeneration in humans with spinal cord injury and paralysis.
The study was published recently in Proceedings of the National Academy of Sciences.
In the study, researchers from Boston University School of Medicine used a pulsed laser to cut neurons and measured the amount of regenerative outgrowth. They discovered that these neurons did not typically regenerate after surgery. However, if they performed the experiments in worms with specific genetic defects or cut two different fibers of one neuron, there was robust regeneration, according to a media release from Boston University Medical Center.
“At the end of development, neurons in the adult human CNS, such as the brain and spinal cord, lose their ability to effectively regenerate in response to injury,” explains Boston University School of Medicine (BUSM) researcher and corresponding author Christopher V. Gabel, PhD, in the release.
“This is why permanent damage and paralysis typically follow CNS injury. “But, when two lesions are made to the same neuron, remarkably, some cells in the human CNS robustly regenerate—a phenomenon known as lesion conditioning and which was strikingly similar to what we saw in our experiments with C. elegans.” adds Gabel, also an assistant professor of physiology and biophysics at BUSM.
Gabel hopes that his team, led by lead author Samuel Chung, PhD, will be able to identify the genes contributing to this effect and suggests that C. elegans can be used as a model to study CNS regeneration in mammals.
“We hope that our findings will invigorate research to enhance the human brain’s innate capacity for regeneration. Ultimately, this could lead to a viable therapy for restoring to full health the many people suffering from permanent neurological damage,” he says in the release.
[Source(s): Boston University Medical Center, Science Daily]