ALS patients with a commonly inherited genetic variation or polymorphism in the interleukin 6 (IL6) receptor gene may experience more severe symptoms and faster progression of the disease, according to a study published recently in the journal Neurology Neuroimmunology & Neuroinflammation.
This relationship was first identified in asthma patients in 2012 by Gregory A. Hawkins, PhD, and co-workers at Wake Forest School of Medicine, part of Wake Forest Baptist Health. He found that people who had asthma and this inherited trait got more severe asthma than those who didn’t.

“We knew that interlukin 6 had many functions in the lung, as shown in asthma, but also in muscle and nerves, all three of which are affected in ALS,” says Carol Milligan, PhD, professor of neurobiology and anatomy at Wake Forest School of Medicine and senior author of the study, in a media release from Wake Forest Baptist Medical Center.

“Therefore, we wondered if what they found in asthma may also have a role in ALS patients or maybe explain why the disease progressed faster in some patients but not others.”

To further an understanding of the factors that influence ALS progression and severity, Milligan and her team conducted an observational, case-controlled retrospective study of two groups of people.

The researchers examined blood and spinal fluid samples, provided by the Northeastern ALS Consortium Biofluid Repository, from 47 participants with ALS and 46 healthy people. Results confirmed that samples from people with ALS who had the variation in the IL6 receptor gene accounted for increased levels of IL6 in blood and spinal fluid compared to the control groups.

To examine if presence of the variation in the IL6 receptor gene might affect disease progression, the investigators examined a second group of 35 patients from the Wake Forest Baptist ALS Center Biorepository that included clinical data collected within a year of symptom onset. The researchers compared the progression of the disease between those who had the polymorphism and those who didn’t. In those with the genetic variation, the disease progressed faster, per the release.

“This study is the first to show that this polymorphism may modify the course of ALS,” Milligan states. “We hope that our findings may provide a target for a new treatment and lay the groundwork for future clinical trials.”

[Source(s): Wake Forest Baptist Medical Center, EurekAlert]